Materials and methods: This study was undertaken on 24 albino rats, in the department of anatomy in Govt. Medical College Jammu. These rats were divided into four groups of 6 rats each. Group A, Group B, Group C rats were painted with 1mg/kg body wt, 2mg/kg body wt and 3 mg/kg body wt of paraphenylene-diamine respectively while Group D rats were painted with distilled water after shaving their backs. Results: There were gross and histological changes in the liver and skin of the albino rats by the repeated topical application of paraphenylene-diamine on the albino rats. Conclusion: Repeated topical application of paraphenylene-diamine results in systemic absorption of the dye and consequent damage of the internal organs.