The whole region of Mizoram in India is well-known for its rich biological and socio-cultural diversity. The local community deeply understands the traditional use of medicinal plants from the forest to treat various ailments. This study was carried out in the Serchhip district of Mizoram, aiming to document the medicinal plant knowledge of the Mizo tribe. Information was gathered by conversing with elderly indigenous individuals living near forested areas. The study identified 34 plant species from 31 genera and 23 families, which are used for treating conditions like allergies, colds, fevers, and wounds. Most of these plants are collected from the wild, with a focus on using leaves for traditional remedies. These findings provide valuable insights for potential pharmaceutical advancements. Integrating scientific knowledge with indigenous practices can benefit both the traditional community and support the conservation of important plant species. Despite the reliance on traditional healing and cultural practices by many locals, there is a critical need to comprehensively protect and record the ethno-botanical knowledge of tribal populations for the benefit of future generations.