Background: All of us have a femininityuniqueness .sexual characteristics refer to an individualinner sense of being male, female, or something else. Transgender individuals experience lots of difficulties in their life that influence their quality of life. Though it cannot be overlooked that in the existing scenario, benefitactions and very recently legal measures, are been taken in terms of accepting that “third gender”,however,a very limited number of research has been done for transgenders,Hence because of this, the current study was designed. Objectives:-The primary objective is to assess the quality of life of transgender people and the secondary objective is to determine the level of quality of life & its association with the demographic variables. Methods:This was a descriptivestudy, conducted among 60 transgender people, residing in,studio chock,Bharatpur, Bhubaneswar, Odisha. The subjects were selected randomly & interviewed through a self-structured demographic Performa &Quality of life tool (WHOQOL-BREF) scale was used to assess the quality of life. Result: As per the survey result,Most of the transgenders are living with average to poor quality of life. Their age, education, occupation, and monthly income has a significant association with the quality of life. Conclusion:This study may bring light to the quality of life of transgender people and as health care professionals we can educate and counsel them to improve their lifestyle.