hrough its varied instances, technologies and applications, biomedical imaging readily lends itself to translational approaches from in-vitro all the way to clinical. Whereas the disciplines, technologies, scales and scopes vary throughout the translational pipeline, they tend to coalesce when reaching the in-vivo context (e.g., through animal models), which ideally then leads to direct evaluation, validation and application in the human. This presentation will focus on demonstrating such a potential through a few in-vivo examples using imaging in a translational context, for providing and exploiting new biomarkers as well as to affect clinical workup, from diagnosis to therapy planning and follow-up. Suggested implementation strategy for suitably supporting such a multidisciplinary effort in the scope of cancer as an example will also be presented.